Can You Build a Tolerance to CBD?

It is rare to develop tolerance to CBD, but it can happen. We know the situation is rare because CBD does not directly bind to our body’s receptors. Also, certain factors can cause people to build a tolerance to CBD.

CBD is one of the most common natural alternatives to manage different neurological disorders. CBD is an abbreviation for Cannabidiol, a primary component of cannabis plants. This chemical has been used in clinical research and remedies for common ailments to relieve pain. 

CBD has also been tested as a treatment for many health conditions related to mental capacity and has shown highly positive results for issues such as anxiety, depression, and post-traumatic stress disorder, even in severe cases. There have been debates about whether it is common for somebody to develop a tolerance to CBD for a long time. Your system can become tolerant to CBD, which hinders its positive effects. However, you can avoid this situation. 

How Drug Resistance Occurs 

cbdLike every other drug, developing tolerance to CBD is a well-known phenomenon. Many reports from users claim a medicine slowly becomes ineffective when they use it over a lengthy period.  

Let’s assume a patient had an allergic reaction to a particular allergen and then they started taking medicine for it. The chances are that they will experience fast results the first time, and the symptoms disappear. But what if every two months, they start experiencing a similar reaction and keep taking the same drug. Usually, the supplement loses potency. 

Our systems develop resistance to treatment when we consume a particular ingredient or drug over an extended period. Our bodies develop immunity to it, i.e., the receptors in the brain no longer get stimulated by the drug. Hence it can no longer work like it used to. If you become tolerant of a particular substance, you must increase the dosage to continue enjoying the effects you desire. 

Now, tolerance to substances may manifest as:

  • Behavioral tolerance (involves psychological parameters)
  • Cellular tolerance(makes cell less responsive to a particular drug)
  • Metabolic tolerance(high metabolism removes the drug from your system before it reaches the target)

The usual dosage we enjoy stops working. Then, we are compelled to increase the quantity we consume to feel the effects. Over time, it gets worse, and the product stops working.

What Happens When CBD Interacts With the Body

CBD is a non-psychoactive chemical synthesized naturally in large amounts. Manufacturers in the hemp industry extract CBD from cannabis plants. Another chemical found in cannabis plants is THC (Tetrahydrocannabinol), a psychoactive compound; that triggers a high sensation when we consume it. These cannabinoids stimulate the endocannabinoid system, a diverse network of cellular receptors. 

Studying this unique neurochemical system allows us to understand how cannabinoids work. The endocannabinoid system comprises of 

  • Endocannabinoids
  • Cannabinoid Receptors (CB1 and CB2)
  • Enzymes

Unlike other cannabinoids, CBD works distinctly when interacting with receptors in the human system. Instead of directly attaching to CB1 and CB2 receptors in the endocannabinoid system, these molecules cause the effects we desire by indirect interaction. The CBD molecules stimulate the production of endocannabinoids by modulating the endocannabinoid production, the CBCs significantly enhance the receptor’s binding affinity. 

Factors That Could Trigger Tolerance to CBD 

Developing a tolerance to substances is a relatively common topic of interest in academia and research. It usually happens in people who are regularly subjected to medication or supplements. Different studies have reported CBD tolerance is not a big deal since, ideally speaking, CBD does not bind with the receptors directly. So, cellular tolerance must be impossible. Yet, developing immunity to CBD is still not impossible.

CBD can be used daily for various reasons. Let us look into the factors that might affect the degree of immunity to CBD in different people. Keep in mind that every person has a different threshold for tolerance, which also varies depending on the following factors:

  • Age
  • Genetics
  • Gender
  • Metabolic Rate
  • Regular dosage
  • CBD consumption
  • Weight
  • Host’s response to CBD
  • The product’s authenticity

What if CBD Is Not Giving Any Effects?

Now, let us discuss why the CBD product you recently bought has not given the impressive effects you enjoy. Have you fallen into a marketing trap? Maybe you think you might have developed immunity based on your early history of drug abuse. Probably not! Here are a few other things to help you investigate your body’s tolerance to CBD:

  • Product Quality

Make sure you know the product’s quality before you buy it. You might have gotten a low-quality product from online sources or inferior quality merchandise from a shop. 

  • Incorrect Dosage

Finding the appropriate dosage is not such an easy task; consult a medical specialist for help or start with a small dose until you discover the quantity that suits your system.

  • Your Physiology

Before assuming CBD does not work for you, check if your body allows you to consume it safely. Otherwise, it is simply pointless for you to keep taking it. 

Reversing CBD Tolerance

Reversing drug tolerance is just the opposite of building tolerance to CBD. Unlike when you need to take an excessive amount to feel a substantial effect, the reverse drug tolerance phenomenon requires the user to limit CBD consumption.

Recent research supports that CBD abuse can cause reverse drug tolerance for a long time. It happens when your body stops the activation of CB1 receptors. This causes cannabinoids such as CBD and THC to be ineffective.


CBD is an organic substance widely used for its health benefits and as a research tool in medical and pharmacological fields. According to the research, resistance to CBD is rare but not impossible. 

There is still much more to learn about CBD functions in our system and developing tolerance. This is so because CBD interactions with the body are quite complex. So, you can use your favorite CBD products in moderation to avoid becoming CBD tolerant.

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