Can You Take CBD and Ibuprofen Together?

CBD oil and ibuprofen don’t need a prescription. It is common to experience pain and inflammation at some point. Ibuprofen is the most accessible medication to get over the counter, even without a doctor’s prescription. However, many people have used natural supplements like CBD for pain relief. While the two are excellent pain relievers, the question remains, can you take CBD and ibuprofen together?

No research has proven that you can’t take CBD with ibuprofen. Yet, you should not take the tablets if you react to any of their components. If you are unsure whether to take the two together, consult your doctor and follow their recommendation.

CBD is one of the naturally occurring compounds in cannabis plants. Many people confuse CBD with marijuana, but they are different. For example, CBD has no psychoactive effects, while marijuana has THC, which is psychoactive and could make you high.

Ibuprofen is a regular pain killer that relieves pain like toothache, period pain, and headache. Additionally, it eliminates inflammations caused by sprains, strains, and other injuries. Besides being a great pain and inflammation reliever, ibuprofen helps with bringing down fever.

Although it is acceptable to take CBD and ibuprofen together, you should do so in moderation to avoid an undesirable outcome. Below is what you need to know if you plan to combine these two products.

How Does CBD Interact With Ibuprofen?

Ibuprofen There is limited information on how CBD interacts with other medications, but research has shown that CBD could limit the enzymes from other medicines that stimulate drug metabolism. In case of adverse side effects from ibuprofen, they could worsen if you take them with CBD. We can classify CBD drug interactions into two:

  • Those that you shouldn’t take with CBD 
  • Those that you can use with CBD but require caution

Ibuprofen falls under the category of those drugs that you can take alongside CBD but needs caution. These two work well together because they undergo a similar metabolization process within the liver. Whether the two increase or decrease their concentration depends on how fast the liver can break down each. As a result, their effects may increase or decrease.

Who Can Use CBD and Ibuprofen Together?

Although there are no official studies on using CBD with ibuprofen, many people have reported positive results from using this combination. You should seek a professional physician’s opinion before taking the combination. You can use the two if you have any of the following problems:

  • Menstrual Pain: If you suffer from menstrual pain and discomfort and dysmenorrhea, you can use a combination of CBD and ibuprofen to reduce the pain.
  • Anxiety and Depression: CBD has antidepressant and anti-anxiety properties. These two help you deal with anxiety and regain your calm. Stress and anxiety can cause inflammation and weaken your immunity, making you vulnerable to illnesses. So, you will need ibuprofen for the pain from the illness and CBD for stress and anxiety.
  • Arthritis: The pain associated with arthritis is sometimes unbearable, and you might want to get fast relief. Sometimes CBD or ibuprofen alone might not work as fast as you would like, so you can take the two pain relievers together to deal with the pain.

How Does CBD and Ibuprofen Work?

Ibuprofen and CBD are products with a lot of research behind them, but it’s essential to understand how they work.

CBD: It is a non-psychoactive substance in cannabis plants, effective in reducing pain and inflammation and treating other conditions. CBD works through interaction with the endocannabinoid system (ECS) in the body. The ECS handles maintaining homeostasis in your body by regulating various vital systems, including sleep, mood, and appetite. Research suggests that CBD may have anti-inflammatory effects, which explains its effectiveness in treating chronic pain and other inflammatory conditions.

Ibuprofen: It is an anti-inflammatory drug made from a chemical called propionic acid. It works by blocking an enzyme that causes inflammation and pain in your body after an injury or sickness. It also blocks these enzymes from producing prostaglandins, which cause stomach ulcers.

Is CBD Safe, and How Is It Different From Ibuprofen?


CBD oil is a natural, non-psychoactive substance extracted from the cannabis plant. Though not FDA-approved as a form of medication, CBD can treat pain, inflammation, stress, and anxiety.

Quality CBD comes from organically grown hemp from specific trusted farms. After harvesting the hemp, it goes through a sophisticated extraction process to extract uncontaminated CBD.

The CBD products undergo independent third-party lab tests to ensure that the end product is pure and safe for human consumption.

The company then publishes the lab findings on its website, where buyers can see them. The manufacturing process occurs in approved facilities to guarantee that the product meets the state’s set health requirements.

CBD provides relief to pain and inflammation naturally, unlike over-the-counter drugs that contain chemicals. CBD provides relief without making you high despite being hemp-derived.

The difference between ibuprofen and CBD lies in how they work to relieve the pain.

While CBD works on pain by interacting with CB2 receptors, ibuprofen stops further prostaglandins production by blocking COX-2. CBD’s pain-relieving mechanism isn’t as straightforward as that of ibuprofen.

CBD relieves pain by signaling the pathways that take a message to the brain, stopping message transmission.

Factors that Determine CBD’s Safety

CBD is safer than THC and other over-the-counter drugs because of its natural ingredients. Regardless, it would help if you take caution when purchasing any CBD product by looking at the following safety measures:

  • THC Concentration

The recommended THC level in CBD is less than 0.3%. If you take a product with more than 0.3% THC, you might get high and become addicted to it, meaning that you will have long-term use. Besides, CBD products with more than 0.3% THC are illegal in the United States.

  • Hemp Source

The only hemp trusted for quality is grown in the United States. This is because of the strict regulation and surveillance. Hemp plants are particularly sensitive and can pick up contaminants from the soil. Therefore, CBD companies have specific farms that don’t apply harmful chemicals to the plants from which they get their hemp. Ensure that you know the hemp source of the brand you intend to buy.

  • Ingredients

CBDNot all CBD products have the same ingredients. While the main element is CBD, additives can make the product more potent through the entourage effect. In addition, it is critical to read through the ingredients list to avoid allergens. You should find the ingredients on the CBD package or on the company’s official website.

  • Quality Test

Reputable brands take their products through lab tests to determine quality and safety. The company gets a Certificate of Analysis (COA) that shows the lab findings after passing the test. The certificate is published on the website, and if you don’t find it, you can request it from the company. If you don’t find a way to access the COA, buy from a different brand that is transparent, as such products may contain harmful additives.

  • Extraction Process

Ensure that your brand of choice has undergone the best extraction process, the most popular being CO2 extraction. However, some shady brands use other techniques that leave harmful residue in the end product. A good extraction process guarantees premium CBD extraction, hence a high-quality product.

Final Thoughts

CBD oil and ibuprofen treat pain and inflammation, so that you can take them together. Ibuprofen also helps treat fever because it reduces your body temperature through perspiration. CBD has similar effects, meaning you can use both to reduce inflammation and fever. You should consult your healthcare provider before mixing CBD oil and ibuprofen because you might need to adjust their doses.

Provided you use CBD and ibuprofen in moderation, you will not suffer from severe side effects. Different body types react differently to specific medications, so consult a medical professional before taking them together. CBD also interacts with enzyme activity, resulting in increased or decreased ibuprofen effects.

Although you can buy CBD and ibuprofen over the counter and take them without a prescription, it would be better to seek a professional’s advice. They will tell you whether you are fit for the combination and recommend a dosage that won’t cause you adverse side effects.

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