Can You Take CBD With Zoloft?

CBD has been the hype of the hemp market for some time now. People love this cannabis compound due to its medicinal benefits. People also love to consume CBD for its recreational uses. CBD is available in various products such as pre-rolls, flower buds, vape cart oils, tinctures, edible oils, and gummies. Moreover, these products are available in multiple flavours and potencies, so you can choose the ones you prefer. 

CBD is derived from the hemp plant of the cannabis species. These plants are different from marijuana because they contain less than 0.3% THC. Therefore, CBD products eliminate the hazard of psychoactive effects and overdose. In addition to that, such a low amount of THC is deemed safe by regulatory bodies. Thus, you can consume these products without worrying about their effects in the long run.

The Frontiers in Immunology Journal published a study in 2018. The study highlighted that CBD exerts antipsychotic, antiepileptic, and anti-anxiety properties. Therefore, you can use CBD to treat anxiety and depression. Moreover, a study conducted at Women’s Hospital, Boston, proves that CBD can help with chronic pain management.

Therefore, it is safe to say that CBD can help deal with depression. This raises a fundamental question, “can you take CBD with Zoloft?” To answer that question, we need to understand what CBD and Zoloft are and how they function.

How Does CBD Work?

CBDCBD is derived from hemp plants. It is one of the 113 compounds discovered so far. Over the years, CBD has shown numerous health benefits. The research around CBD has proven that it plays a significant role in activating Endocannabinoid System (ECS). The ECS is responsible for maintaining the optimal functioning of our brain. 

It comprises endogenous cannabinoids that attach to CB1 and CB2 receptors in the body. The cannabinoid molecules bind to the specific receptors on the cells and send the appropriate signal to your brain. These components help maintain a healthy mental environment and combat issues like anxiety, stress, and PTSD. 

Due to poor eating habits and stressful routines, our bodies lose the ability to produce enough endocannabinoids. This results in a slowed ECS functioning leading to poor mental health. Therefore, people resort to CBD products to get that boost of cannabinoids. 

What Is Zoloft, and Why Do People Take It?

Physicians generally prescribe antidepressants to people dealing with depression. These medications are not a foolproof cure for depression, but they can help lessen the symptoms. However, you should not take your physical and mental health lightly regarding medicine. Although these medications help you, mixing them with other products can lead to severe reactions. 

Zoloft (Sertraline) is a prescription drug that people use to deal with depression. It belongs to the SSRI class of Antidepressants. Jama International Medicine Journal published an article in 2013. The report focused on the prevalence of depression among Americans. According to the survey presented in the article, 1 out of every 6 American adults took prescribed antidepressants that year to treat depression or other similar conditions.

What Are SSRIs?

Serotonin, the feel-good hormone, is a natural neurotransmitter. It is responsible for happiness and elevated mood. The decline in serotonin levels can lead to feelings of unhappiness and bad moods. The prolonged decline can even lead to depression in people. 

Therefore, doctors prescribe artificial serotonin generators to make up for the loss. These medicines are called antidepressants and are available in numerous types. SSRIs are Selective Serotonin Reuptake Inhibitors. These are antidepressants that work by boosting serotonin levels in your body. These medicines improve the patients’ general well-being and mental health 2 to 4 weeks after starting the course.

Fluoxetine was the first SSRI antidepressant that was manufactured in the 1990s. It changed the way people treated depression. Before SSRIs, the physicians recommended tricyclic antidepressants, which are non-selective, broad-spectrum medicines. Some other types of FDA-approved SSRIs include Citalopram (Celexa), Escitalopram (Lexapro), and Paroxetine (Paxil, Pexeva).

Side Effects of Zoloft? 


There is no denying that these medications bring relief to people. However, they come with specific side effects. The most commonly reported side effects of Zoloft include headache and fatigue. Moreover, insomnia, gastrointestinal problems, and anxiety can result from taking a lower than required SSRI dosage. 

Additionally, abruptly stopping the intake of Zoloft can also result in severe side effects. These include stomach problems, anxiousness, sweating, irritability, confusion, and insomnia. Therefore, it is best to consult a doctor and follow a prescribed dosage. Taking medicine on your own can pose severe threats to your health. 

Can You Take CBD With Zoloft?

Now, coming back to the original topic under consideration, is mixing CBD with Zoloft safe for us? People generally tend to combine CBD with other products to enhance the effects of CBD. There is enough evidence that mixing Zoloft with drinks like alcohol or even grape juice can show adverse effects. People reported low blood pressure, sedation, and drowsiness. However, there is little research on how CBD and Zoloft act when mixed.

The drug interaction database shows that mixing CBD and Zoloft might reduce the efficacy of Zoloft. Additionally, CBD might enhance the side effects of Zoloft, making it worse for people already dealing with depression. Moreover, CBD may contribute to blocking the performance of some liver enzymes. This can lead to poor absorption of antidepressants into the bloodstream.

The reason is that there are certain enzymes (CYP34A) that your body requires. These enzymes help your liver break down and absorb certain drugs. A study shows that CBD can interfere with the metabolizing ability of these enzymes. Therefore, the drugs do not exert their effect. Moreover, over time, the excess cumulation of these drugs in the body leads to other complications.

Therefore, it is not safe for you to mix CBD with Zoloft to answer the question. If you are dealing with depression, it is best to consult a physician and determine what kind of medication is suitable for you. Additionally, refrain from mixing prescribed medicines with other products by consulting your doctor first.  


Both CBD and Zoloft have their pros when it comes to treating depression. However, mixing the kinds of medicines is never a good idea. People are mostly inclined to mix CBD and Zoloft to experience enhanced effects. However, if you are not a professional, you might create severe problems for your body.

Although the information on the interaction between CBD and Zoloft is limited, health risks are involved. Mixing the two can enhance the severity of side effects such as headaches, drowsiness, dizziness, and loss of focus and concentration. Moreover, the combination can also affect the efficiency of your liver, allowing the components of drugs to accumulate in your body.   

If you are dealing with depression or taking prescribed medication, it is better to take the advice of a professional. Your doctor might be able to determine whether Zoloft is a better option for you or CBD. This will help you make an informed decision. This way, you can avoid inconvenience and health complications in the future. 

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